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The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma

期刊: DRUG DELIVERY, 2023; 30 (1)

Temozolomide (TMZ) is a conventional chemotherapeutic drug for glioma, however, its clinical application and efficacy is severely restricted by its dr......

Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice

期刊: DRUG DELIVERY, 2023; 30 (1)

Induction of oral tolerance by vaccination with type 1 diabetes mellitus (T1DM)-associated autoantigens exhibits great potential in preventing and tre......

Multifunctional cell membranes-based nano-carriers for targeted therapies: a review of recent trends and future perspective

期刊: DRUG DELIVERY, 2023; 30 (1)

Nanotechnology has ignited a transformative revolution in disease detection, prevention, management, and treatment. Central to this paradigm shift is ......

First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring

期刊: DRUG DELIVERY, 2023; 30 (1)

Polymeric drug-releasing vaginal rings are useful for both local and systemic administration of drugs via the intravaginal route. Typically, they prov......

A comprehensive review on recent nanosystems for enhancing antifungal activity of fenticonazole nitrate from different routes of administration

期刊: DRUG DELIVERY, 2023; 30 (1)

This review aims to comprehensively highlight the recent nanosystems enclosing Fenticonazole nitrate (FTN) and to compare between them regarding prepa......

Utilization of experimental design in the formulation and optimization of hyaluronic acid-based nanoemulgel loaded with a turmeric-curry leaf oil nanoemulsion for gingivitis

期刊: DRUG DELIVERY, 2023; 30 (1)

Numerous problems affect oral health, and intensive research is focused on essential oil-based nanoemulsions that might treat prevent or these problem......

Silk nanoparticles for the protection and delivery of guava leaf (Psidium guajava L.) extract for cosmetic industry, a new approach for an old herb

期刊: DRUG DELIVERY, 2023; 30 (1)

Guava (Psidium guajava L.) is a well-known plant containing high levels of natural antioxidants, the phenolic compounds, which have been employed in n......

Stability of polymeric cationic niosomes and their plasmid DNA-based complexes as gene delivery carriers

期刊: DRUG DELIVERY, 2023; 30 (1)

This study aims to explore the stability of lipo-polymeric niosomes/niosome-based pCMS-EGFP complexes under different storage temperatures (25 degrees......

Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation

期刊: DRUG DELIVERY, 2023; 30 (1)

The present research study limns the preparation of MNF loaded transethosomes (MNF-TE) to improve MNF solubility, bioavailability and permeation throu......

In-depth study of anticancer drug diffusion through a cross-linked -pH-responsive polymeric vesicle membrane

期刊: DRUG DELIVERY, 2023; 30 (1)

Post-encapsulation and release of the anticancer drug doxorubicin hydrochloride (DOX center dot HCl) through cell-like transmission functions of polym......

Platinum-based drugs and hydrogel: a promising anti-tumor combination

期刊: DRUG DELIVERY, 2023; 30 (1)

Platinum-based drugs are widely used as first-line anti-tumor chemotherapy agents. However, they also have nonnegligible side effects due to the free ......

Sonodynamic therapy of glioblastoma mediated by platelets with ultrasound-triggered drug release

期刊: DRUG DELIVERY, 2023; 30 (1)

Sonodynamic therapy (SDT) has aroused great interest for its potential in the treatment of glioblastoma (GBM). SDT relies on tumor-selective accumulat......

Advance in placenta drug delivery: concern for placenta-originated disease therapy

期刊: DRUG DELIVERY, 2023; 30 (1)

In the therapy of placenta-originated diseases during pregnancy, the main challenges are fetal exposure to drugs, which can pass through the placenta ......

M6P-modified solid lipid nanoparticles loaded with matrine for the treatment of fibrotic liver

期刊: DRUG DELIVERY, 2023; 30 (1)

Liver fibrosis is a key pathological process shared by the progression of various chronic liver diseases. Treatment of liver fibrosis can effectively ......

Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor

期刊: DRUG DELIVERY, 2023; 30 (1)

Transcatheter arterial chemoembolization (TACE) is usually considered more efficacious in the local treatment of parenchyma-sparing hepatocellular car......

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